This research investigates the challenges of enforcement of patent rights in geographically divisible inventions. It considers aspects of technological progress which pose challenges to the established system of patent protection based on the territorial limitation of rights. The analysis focuses on substantive patent law, especially on the infringement provisions. It is carried out in the context of Internet-related inventions, which demonstrate an extraordinarily construed technical nature, namely geographical divisibility. This leads to the development of a research question of whether the infringement standard is appropriate in relation to the technological development in ICTs. This avenue of research is motivated by two sets of arguments. On the one hand side, the courts in Germany, United Kingdom, and the United States affirmed the specific and different nature of Internet-related inventions. On the other hand side, the foundations of patent law assure the right-holder the possibility to enforce the right against any infringer. Should it be the case that territorial limitation of patent rights prevents the right holder from enforcing the patent in a geographically divisible invention, it would render patents on such inventions meaningless, which would remove the reasons to use the patent system.